Honors and Awards
 Fellow, American Association for the Advancement of Science, 2005
Research Interests
Michael Nachman and the members of his lab study population, evolutionary, and ecological genetics and genomics. Most work is on mammals with particular emphasis on mice and humans. Research is focused on understanding the forces that shape genetic variation in natural populations. A first major area of research is aimed at uncovering the extent to which natural selection can be detected in patterns of DNA sequence variation, and in particular, in understanding the joint effects of selection and recombination in determining the distribution of genetic variation. A second area of interest is the genetics of speciation. This includes studies to understand the origin and consequences of specific mutations that may limit gene flow between populations and closely related species. A third main area of interest is ecological genetics, aimed at uncovering the genetic basis of traits that are known to be important ecologically. This includes studies on the genetic basis of adaptive melanism in mice.
Visit Michael Nachman's website.
Selected Publications
- Nachman, M.W. and P. Myers, 1989. Exceptional chromosomal mutations in
a rodent population are not strongly underdominant. Proc. Nat. Acad.
Sci. 86: 6666-6670.
- Nachman, M.W., S.N. Boyer, J.B. Searle, and C.F. Aquadro, 1994
Mitochondrial DNA variation and the evolution of Robertsonian
chromosomal races of house mice, Mus domesticus. Genetics 136: 1105-1120.
- Nachman, M.W., S.N. Boyer, and C.F. Aquadro, 1994 Non-neutral evolution
of the NADH dehydrogenase subunit 3 gene in mice. Proc. Nat. Acad. Sci.
91: 6364-6368.
- Nachman, M.W., and J.B. Searle, 1995 Why is the house mouse karyotype so
variable? Trends Ecol. Evol. 10: 397-402.
- Nachman, M.W., and G.A. Churchill. 1996 Heterogeneity in rates of
recombination across the mouse genome. Genetics 142: 537-548.
- Nachman, M.W., W.M. Brown, M. Stoneking, and C.F. Aquadro, 1996
Nonneutral mitochondrial DNA variation in humans and chimpanzees.
Genetics 142: 953-963.
- Nachman, M.W., 1997. Patterns of DNA variability at X-linked loci in
Mus domesticus. Genetics 147: 1303-1316.
- Nachman, M.W., 1998. Deleterious mutations in animal mitochondrial DNA.
Genetica 102/103: 61-69.
- Nachman, M.W., V.L. Bauer, S.L. Crowell, and C.F. Aquadro, 1998 DNA
variability and recombination rates at X-linked loci in humans.
Genetics 150: 1133-1141.
- Nachman, M.W., 1998 Y-chromosome variation of mice and men. Mol. Biol.
Evol. 15: 1744-1750.
- Karn, R.C., and M.W. Nachman, 1999. Reduced nucleotide variability at
the salivary androgen-binding locus in house-mice; evidence for positive
natural selection. Mol. Biol. Evol. 16: 1192-1197.
- Nachman, M.W., and S.L. Crowell, 2000. Estimate of the mutation rate
per nucleotide in humans. Genetics 156: 297-304.
- Gilad, Y., D. Segre, K. Skorecki, M.W. Nachman, D. Lancet, and D.
Sharon, 2000. Dichotomy of single-nucleotide polymorphism haplotypes in
olfactory receptor genes and pseudogenes. Nature Genetics 26: 221-224.
- Payseur, B.A., and M.W. Nachman, 2000. Microsatellite variation and
recombination rate in the human genome. Genetics 156: 1285-1298.
- Riginos, C., and M.W. Nachman, 2001. Population subdivision in marine
environments: the contributions of isolation by distance, discontinuous
habitat, and biogeography to genetic differentiation in a blennioid
fish, Axoclinus nigricaudus. Molecular Ecology 10: 1439-1453.
- Nachman, M.W. 2001. Single nucleotide polymorphisms and recombination
rate in humans. Trends in Genetics 17: 481-485.
- Payseur, B.A., A.D. Cutter, and M.W. Nachman, 2002. Searching for
evidence of positive selection in the human genome using patterns of
microsatellite variability. Mol. Bio. Evol. 19: 1143-1153.
- Nachman, M.W. 2002 Variation in recombination rate across the genome:
evidence and implications. Curr. Op. Genet. Devel. 12: 657-663.
- Saunders, M.A., M.F. Hammer, and M.W. Nachman, 2002. Nucleotide
variability at G6pd and the signature of malarial selection in humans.
Genetics 162:1849-1861.
- Nachman, M.W., Hoekstra, H.E., and S.L. D'Agostino, 2003. The genetic
basis of adaptive melanism in pocket mice. Proc. Nat. Acad. Sci. USA
100: 5268-5273.
- Storz, J.F. and M.W. Nachman, 2003. Natural selection on protein
polymorphism in the rodent genus Peromyscus: evidence from interlocus
contrasts. Evolution 57: 2628-2635.
- Nachman, M.W., S.L. D'Agostino, C.R. Tillquist, Z. Mobasher, and M.F.
Hammer, 2004. Nucleotide variation at Msn and Alas2, two genes
flanking the centromere of the X chromosome in humans. Genetics 167:
423-437.
- Hoekstra, H.E., K.E. Drumm, and M.W. Nachman, 2004. Ecological genetics
of adaptive color polymorphism in pocket mice: geographic variation in
selected and neutral genes. Evolution 58: 1329-1341.
- Storz, J.F., B.A. Payseur, and M.W. Nachman, 2004. Multilocus scans of
microsatellite variability in humans reveal evidence for selective
sweeps outside of Africa. Mol. Biol. Evol. 21: 1800-1811.
- Rosenblum, E.B., H.E. Hoekstra, and M.W. Nachman, 2004. Adaptive
reptile color variation and the evolution of the Mc1r gene. Evolution
58: 1794-1808.
- Hammer, M.F., D. Garrigan, E. Wood, J.A. Wilder, Z. Mobasher, A. Bigham,
J.G. Krenz, and M.W. Nachman, 2004. Heterogeneous patterns of variation
among multiple X linked loci: the possible role of diversity reducing
selection in non-Africans. Genetics 167: 1841-1853.
- Payseur, B.A., J.G. Krenz, and M.W. Nachman, 2004. Differential
patterns of introgression across the X chromosome in a hybrid zone
between two species of house mice. Evolution 58: 2064-2078.
- Nachman, M.W. 2005. The genetic basis of adaptation: lessons from
concealing coloration in pocket mice. Genetica 123: 125-136.
- Payseur, B.A., and M.W. Nachman, 2005. The genomics of speciation:
investigating the molecular correlates of X chromosome introgression
across the hybrid zone between Mus domesticus and Mus musculus.
Biol. J. Linn. Soc 84: 523-534.
- Good, J.M., and M.W. Nachman, 2005. Rates of protein evolution are
positively correlated with developmental timing of expression during
mouse spermatogenesis. Mol. Biol. Evol. 22: 1044-1052.
- Saunders, M.A., M. Slatkin, C. Garner, M.F. Hammer, and M.W. Nachman,
2005. The extent of linkage disequilibrium caused by selection on
G6PD in humans. Genetics 171: 1219-1229.
- Wood, E.T., D.A. Stover, M. Slatkin, M.W. Nachman, and M.F. Hammer,
2005. The beta-globin recombinational hotspot reduces the effects of
genetic hitchhiking around HbC, a recently arisen mutation providing
resistance to malaria. American Journal of Human Genetics 77: 637-642.
- Nachman, M.W., 2006 Detecting selection at the molecular level. In:
Evolutionary Genetics, Concepts and Case Studies, edited by C.W. Fox
and J.B. Wolf. Oxford University Press, Oxford.
- Geraldes, A., N. Ferrand, and M.W. Nachman, 2006. Contrasting patterns
of introgression at X-linked loci across the hybrid zone between
subspecies of the European rabbit (Oryctolagus cuniculus). Genetics
173: 919-933.
- Dean, M.D., K.G. Ardlie, and M.W. Nachman, 2006. The frequency of
multiple paternity suggests that sperm competition is common in house
mice (Mus domesticus). Molecular Ecology 15: 4141-4151.
- Saunders, M.A., J.M. Good, E.C. Lawrence, R.E Ferrell. W-H. Li, and M.W.
Nachman, 2006. Humand adaptive evolution at Myostatin, a regulator of
muscle growth. American Journal of Human Genetics 79: 1089-1097.
- Storz, J.F., S.J. Sabatina, E.J. Gering, H. Moriyama, N. Ferrand, B.
Montiero, and M.W. Nachman, 2007. The molecular basis of high-altitude
adaptation in deer mice. PLoS Genetics 3: 448-459.
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