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Dr. Carlos A. Machado, Assistant Professor

Positions and Education
Assistant Professor; Ecology & Evolutionary Biology, University of Arizona, 2003-present
Postdoctoral Fellow (1998-2002) Department of Genetics, Rutgers University
Ph.D. Ecology and Evolutionary Biology (1998), University of California, Irvine
B.S. Biology (1992) Universidad Nacional de Colombia, Bogotá, Colombia
Honors and Awards
1994-1998 Howard Hughes Medical Institute Predoctoral Fellowship
1994 Short Term Fellowship, Smithsonian Tropical Research Institute (STRI)
1992-1993 EXXON and Intern Fellowships for Latin American students, STRI

Research Interests

Carlos A. Machado is an evolutionary geneticist interested in a range of topics that include the genetics of species divergence, plant-insect coevolution, population genetics, and phylogenetics. Dr. Machado is currently interested in understanding the processes and mechanisms that have led to the evolution of new species and to the increase in species diversity in two main study systems: the fig/fig-wasp mutualism and Drosophila pseudoobscura and its close relatives. The main problems that he is addressing in these two systems are: 1) understanding the importance of hybridization and introgression during the evolution of new species; 2) identifying genetic changes involved in the evolution of regulatory hybrid dysfunction (gene expression changes affecting fertility or viability) in closely related species of Drosophila. Dr. Machado is also interested in the evolution of the human parasite Trypanosoma cruzi.

Visit Carlos Machado's website

Read a profile of Carlos Machado in the Fall 2003 (Winter 2004) issue of Desert News & Views (pdf file)

PubMed list of publications for Carlos Machado
Selected Publications

  1. Machado C. A., Haselkorn T. S., Noor M. A. F. (2007) Evaluation of the genomic extent of effects of fixed inversion differences on intraspecific variation and interspecific introgression in Drosophila pseudoobscura and D. persimilis. Genetics 175: 1289-1306

  2. Marussich W., Machado C. A. (2007) Host-specificity and coevolution among pollinating and non-pollinating New World fig wasps. Mol. Ecol. 16: 1925–1946

  3. Matzkin L. M., Watts T. D., Bitler B. G., Machado C. A., Markow T. A. (2006) Functional genomics of cactus host shifts in Drosophila mojavensis. Mol. Ecol. 15: 4635-4643

  4. Ranz, J. M., Machado C. A. (2006) Uncovering evolutionary patterns of gene expression using microarrays. Trends Ecol. Evol. 21: 29-37

  5. Machado, C. A., Robbins, N., Gilbert, M. P. T., Herre E. A. (2005) Critical review of host specificity and its coevolutionary implications in the fig/fig-wasp mutualism. Proc. Natl. Acad. Sci. USA 102: 6558-6565

  6. Molbo, D., Machado, C. A., Sevenster, J. G., Keller L., Herre E. A. (2003) Cryptic species of fig-pollinating wasps: implications for the evolution of the fig-wasp mutualism, sex allocation, and precision of adaptation. Proc. Natl. Acad. Sci. USA 100: 5867-5872

  7. Machado C. A., Hey J.  (2003) The causes of phylogenetic conflict in a classic Drosophila species group. Proc. R. Soc. Lond. B 270: 1193-1202

  8. Machado C. A., Kliman R. M., Markert J., Hey J. (2002) Inferring the history of speciation from multilocus DNA sequence data: the case of Drosophila pseudoobscura and close relatives. Mol. Biol. Evol. 19: 472-488

  9. Machado C. A., Ayala F. J. (2001) Nucleotide sequences provide evidence of genetic exchange among distantly related lineages of Trypanosoma cruzi. Proc. Natl. Acad. Sci. USA 98: 7396-7401

  10. Machado C. A, Jousselin E., Kjellberg F., Compton S. G., Herre E. A. (2001) Phylogenetic relationships, historical biogeography, and character evolution of fig pollinating wasps. Proc. R. Soc. Lond. B 268: 685-694

  11. West S. A., Murray M. G., Machado C. A., Griffin A. S., Herre E. A. (2001) Testing Hamilton’s rule with competition between relatives. Nature 409: 510-513
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